HPE P55245-B21 – ProLiant DL380 Gen10 Plus Rack Server (2U)

HPE P55245-B21 – ProLiant DL380 Gen10 Plus Rack Server (2U)

Overview

The HPE P55245-B21 is a 2U rack-mounted enterprise server based on the ProLiant DL380 Gen10 Plus platform. It is deployed in data center environments for virtualization, cloud infrastructure, database hosting, and general-purpose enterprise compute workloads. The system is designed for scalability, high availability, and centralized management in rack-based infrastructure.

The configuration is built around an Intel Xeon Silver 4309Y processor with 8 cores and 16 threads, operating at 2.8 GHz base frequency. It supports dual-socket architecture depending on configuration, allowing compute scaling within the same platform family. The system typically ships with 32GB DDR4 ECC memory in base configurations and supports large memory expansion for enterprise workloads.

For storage, the platform supports up to 8 SFF (Small Form Factor) hot-swap drive bays with compatibility for SAS, SATA, and NVMe drives depending on backplane configuration. It integrates HPE Smart Array storage controllers such as MR-series adapters, enabling RAID protection and performance optimization for enterprise storage workloads.

The system is designed for modern data center environments requiring flexible I/O expansion, including PCIe Gen4 slots for network, storage, and accelerator cards. It integrates into HPE’s iLO 5 management ecosystem, enabling remote provisioning, monitoring, and lifecycle control for large-scale deployments.

In deployment, this server is commonly used for virtualization clusters (VMware, Hyper-V, KVM), private cloud infrastructure nodes, and mid-tier database or application servers. It is also used in infrastructure consolidation projects where multiple legacy servers are replaced with higher-density compute nodes.

The platform is not intended for edge or desktop use, as it requires rack infrastructure, redundant power, and enterprise cooling systems to operate effectively.

Typical Deployment Scenarios

• Virtualization clusters in enterprise data centers
• Private cloud compute nodes with centralized orchestration
• Database and transactional application hosting
• Rack consolidation and infrastructure modernization
• Mid-tier enterprise application servers

Technical Specifications

Compatibility / Ecosystem

The HPE P55245-B21 integrates into HPE enterprise infrastructure ecosystems including ProLiant rack environments and iLO-based remote management systems. It supports virtualization platforms such as VMware ESXi, Microsoft Hyper-V, and Linux KVM. The server is compatible with HPE Smart Array controllers and modern NVMe/SAS/SATA storage ecosystems, making it suitable for hybrid enterprise workloads and scalable data center deployments.