HPE P52561-421 – ProLiant DL380 Gen11 2U Rack Server

HPE P52561-421 – ProLiant DL380 Gen11 2U Rack Server

Overview

The HPE P52561-421 is a ProLiant DL380 Gen11 enterprise rack server designed for data center workloads requiring scalable compute performance, high memory bandwidth, and flexible storage architecture. It is deployed in virtualization clusters, enterprise databases, cloud infrastructure nodes, and application hosting environments where consistent performance and hardware redundancy are essential.

The system is based on the Intel Xeon Gold 5416S processor with 16 cores and a base frequency of 2.0 GHz. It supports Intel’s Xeon Scalable architecture with dual-socket capability, allowing future expansion to higher compute density configurations depending on workload requirements. The platform is engineered for DDR5 memory, providing increased bandwidth for virtualization and memory-intensive applications.

The chassis uses an 8 × 2.5-inch SFF hot-plug drive bay design supporting SAS, SATA, and NVMe storage options depending on controller selection. This enables mixed storage tier deployments, combining high-speed SSDs for performance with capacity drives for bulk storage within the same system.

For I/O expansion, the DL380 Gen11 supports PCIe Gen5 slots and OCP networking modules, enabling integration of high-throughput NICs, storage accelerators, and GPU cards. This makes it suitable for modern enterprise workloads including virtualization clusters and containerized environments.

In deployment, this server is typically installed in standardized 2U rack infrastructure across enterprise data centers. It is used as a compute node in clustered environments running VMware ESXi, Microsoft Hyper-V, or Linux-based Kubernetes platforms.

A practical deployment scenario includes virtualization clusters where multiple servers share centralized SAN or NVMe storage, supporting production workloads with redundancy and failover capabilities.

This system is not intended for small office deployments or lightweight edge computing due to its power, cooling, and rack infrastructure requirements.

Typical Deployment Scenarios

• Enterprise virtualization and VMware clusters
• Cloud infrastructure and container nodes
• Database and transactional application hosting
• Software-defined storage environments
• High-density rack compute deployments

Technical Specifications

Compatibility / Ecosystem

The HPE P52561-421 integrates into HPE ProLiant Gen11 enterprise ecosystems supporting VMware ESXi, Microsoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise, and Ubuntu Server. It supports SAS/SATA/NVMe storage configurations and PCIe Gen5 expansion for networking and accelerator hardware. The platform is managed through HPE iLO 6 for remote provisioning, monitoring, and lifecycle control in enterprise environments.